MEET NINA

Your noninvasive
neuromodulation assistant

Drug-Free, Noninvasive, At-Home Therapy For OAB

For patients who don’t want to take another pill and aren’t ready for surgery, NiNA* may be an ideal alternative to medication. NiNA uses proprietary technologies to optimally target and activate the saphenous while maintaining user comfort. This simple, discreet system for the treatment of OAB requires just 30 minutes of stimulation and is designed to deliver significant, durable symptom reduction all done in the convenience of your own home.

85%

Physicians would prescribe NiNA to 85% of their OAB patients 1

3 to 1

patients prefer NiNA to medications 3 to 12

85%

Physicians would prescribe NiNA to 85% of their OAB patients 1

3 to 1

patients prefer NiNA to medications 3 to 12

Initial nSAFN clinical experience demonstrates efficacy on-par with published results for medications and other competing therapies

Noninvasive Saphenous Neuromodulation (nSAFN) has been studied in 3 feasibility studies to date at 7 centers in the US and Canada.3

78%

OAB responders3,4

65%

UUI responders3

85%

UUI reduction in UUI
responders3

28%

of patients were Dry3

NiNA vs Competitive Therapies

Medications

Drugs have significant side-effects including dry mouth, constipation and upset stomach…

…NiNA has no serious adverse effects and is used only 2-3 times per week3.

Percutaneous Tibial Neuromodulation (PTNS/PTNM)

PTNS requires scheduled weekly office visits, and can cause bleeding and swelling…

…NiNA is done at home and is completely noninvasive with no serious adverse effects.

Sacral Neuromodulation (SNS/SNM)

SNS requires a surgical implant with a possibility of surgical revision5

…NiNA is placed on the surface of the skin, and removed by the patient in just 30m time at home.

Botulinum Toxin

Botulinum toxin requires in-office injections into the bladder wall every 6 months and may cause urinary tract infections, urinary retention6

…NiNA is done at home and is completely noninvasive with no serious adverse effects

the Future of NiNA

An Intelligent Companion App and Ecosystem

Not only does NiNA offer revolutionary at-home neuromodulation therapy, but the introduction of the NiNA CareTM app7 will also add comprehensive educational content developed by world-renowned physicians– maximizing patient engagement and the potential for successful, durable outcomes.

1Primary market research study, conducted by third party Q2-2021, data on file.

2Primary market research study, conducted by third party Q1-2021, data on file.

3Feasibility clinical outcomes, data on file.

4Defined as >=50% reduction or return to normal voiding. UUI = urinary urge incontinence.

5Brazzelli, M., et al. (2006). Efficacy and safety of sacral nerve stimulation for urinary urge incontinence: a systematic review. The Journal of Urology, 175(3 Pt 1), 835–841. 

6Nitti, V. W., et al. (2013). OnabotulinumtoxinA for the treatment of patients with overactive bladder and urinary incontinence: results of a phase 3, randomized, placebo controlled trial. The Journal of Urology, 189(6), 2186–2193.

7NiNA Care is currently in development and has not received market authorization for sale in the US, Canada, or any other geography.